老年2型糖尿病患者血糖变异性与糖尿病肾病的关系

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张艳;余维巍;姚济华;李彩萍;张存泰;余学锋

【期刊名称】《实用医学杂志》【年(卷),期】2013(029)002

【摘要】Objective To investigate association of glycemic variability and severity of diabetic nephropathy in elderly patients with type 2 diabetes. Methods One hundred and fourteen elderly patients with type 2 diabetes were enrolled and divided into 3 groups according to 24 h urinary albumin excretion rate. The 3 groups are as follows: the diabetes group (DM, n = 36), the early diabetic nephropathy group (EDN, n = 44) and the clinical diabetic nephropathy group (DN, n = 34). Systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood sugar (FBG), hemoglobin Alc(HbAlc), serum creatinine (Scr), serum cystatin C (Cys C) were determined, and blood glucose level was monitored with continuous glucose monitor system (CGMS). The standard deviation of mean blood glucose (SDBG), the mean amplitude of glycemic excursions (MAGE), the largest amplitude of glycemic excursions (LAGE), the area under curve (AUC) and the absolute means of daily differences (MODD) were also calculated. Results SBP, DBP, HbA1c, sCr and Cys C of DN group were significantly increased than those in the EDN and in the DM groups (P < 0.05), Cys C in the EDN group was significantly higher than that in the DM group (P < 0.05), levels of the SDBG, MAGE, LAGE,

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