毕 业 论 文
（ 2012 届）
题 目 化妆品美白剂（VC乙基醚）
合成及条件优化
学 院 化学化工学院 专 业 化学分析 年 级 08级 学生学号 12008240014 学生姓名 李亚辉 指导教师 麻晓霞
2011 年 11 月 06
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化妆品美白剂（VC乙基醚）合成及条件优化
摘要：L-抗坏血酸，即维生素C(简称VC)，参与很多体内的生理活动，不仅作为药物在保持和促进人体健康中起到重要的作用，而且作为酸味剂、还原剂、抗氧化剂、漂白剂和稳定剂用于化妆品和食品中。但是VC容易被氧化且脂溶性较差，使得VC在应用上受到了很大地限制。本研究通过对VC的3-位羟基结构进行修饰，通过单因素和正交试验优化合成条件，旨在缩短反应时间，提高产率，增强VC的稳定性和脂溶性。
关键词：L-抗坏血酸；合成；3-O-乙基抗坏血酸
Cosmetics beautiful Bai Ji (the VC ethyl ether) synthesizes and
the condition optimization
Abstract: L- antiscorbutic acid, namely Vitamin C (i.e. VC), participation very polysome in physiological activity, not only took the medicine plays the vital role in the maintenance and in the promotion human body health, moreover as the sour odor medicinal preparation, the reducing agent, the oxidation inhibitor, the bleaching agent and the stabilizer uses in the cosmetics and food.But VC is oxidized easily also the fat soluble is bad, causes VC to receive in the application has limited very greatly.This research through carries on the beautification to the VC 3- hydroxyl structure, through the single factor and the orthogonal experiment optimization synthesis condition, is for the purpose of reducing the reaction time, enhances the production rate, strengthens VC the stability and the fat soluble.
Keywords: L-ascorbic acid; synthesis; 3-O-ethyl ascorbic acid
L- antiscorbutic acid; Synthesis; 3-O- ethyl antiscorbutic acid
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目录
第一章 引言 ............................................................................................................................. 1
1.1 论文综述 ........................................................................................................................... 1 1.2 论文的依据 ....................................................................................................................... 2 1.3 论文研究的意义 ............................................................................................................... 3 第二章 实验部分 ........................................................................................................................... 4
2.1仪器及试剂 ........................................................................................................................ 4 2.2实验方法 ............................................................................................................................ 5
2.2.1 试剂预处理 ........................................................................................................... 5 2.2.2色谱条件 ................................................................................................................ 5 2.2.3 3-O-乙基维生素C的标准曲线 ........................................................................... 5 2.2.4 样品溶液的制备 ................................................................................................... 5 2.2.5 3-O-乙基维生素C的结晶 ................................................................................... 6 2.3结果与讨论 ........................................................................................................................ 6
2.3.1 3-O-乙基维生素C 的表征 ................................................................................ 6 2.3.2 色谱分析 ............................................................................................................... 6 2.3.3 线性实验 ............................................................................................................... 7
第三章 合成条件优化 ................................................................................................................... 8
3.1 单因素试验 ..................................................................................................................... 8
3.1.1 微波反应时间对产率的影响 ............................................................................. 8 3.1.2 n(VC)：n(三乙胺)对产率的影响 ..................................................................... 8 3.1.3 n(VC)：n(硫酸二乙酯)对产率的影响 ............................................................. 9 3.1.4微波功率对产率的影响 ...................................................................................... 10 3.2 正交试验 ....................................................................................................................... 10 第四章 结论 ................................................................................................................................. 12 参考文献......................................................................................................................................... 13 附表 ................................................................................................................................................ 14 致 谢........................................................................................................................................... 16
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宁夏大学本科毕业论文 制作方程式
制作方程式：
NCHCHONH2+OHOH
和：
CH3HCCH第一步HXH3CCHCH3第二步XH3CCHXCH34 4
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