北京诺禾致源生物信息科技有限公司
12．差异基因蛋白互作网络分析
对差异分析中所产生的差异基因列表，在STRING数据库中找出这些差异基因间的互作关系，并将得到的互作数据导入 Cytoscape 软件实现互作网络的可视化。蛋白质互作数据来源于STRING数据库（http://string-db.org/）。
互作网络如下图所示，其中节点（node）的大小与此节点的度（degree）成正比，即与此节点相连的边越多，它的度越大，节点也就越大。节点的颜色与此节点的聚集系数（clustering coefficient）相关，颜色梯度由绿到红对应聚集系数的值由低到高；聚集系数表示此节点的邻接点之间的连通性好坏，聚集系数值越高表示此节点的邻接点之间的连通性越好。边（edge）的宽度表示此边连接的两个节点间的互相作用的关系强弱，互相作用的关系越强，边越宽。
46 北京诺禾致源生物信息科技有限公司
图11 差异基因互作网络图
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