IL-10-Producing Type 1 Regulatory T Cells and Allergy

IL-10-Producing Type 1 Regulatory T Cells and

Allergy

Kui Wu;Yutian Bi;Kun Sun;Changzheng Wang

【期刊名称】《中国免疫学杂志（英文版）》 【年(卷),期】2007(004)004

【摘要】As an important subset of regulatory T (Treg) cells, IL-10-producing type 1 regulatory T cells (Tr1), have some different features to thymic-derived naturally occurring CD4+CD25+Foxp3+ Treg cells(nTreg cells). Similar to nTreg cells, Tr1 also play important roles in the control of allergic inflammation in several ways. There is a fine balance between Tr1 and Th2 responses in healthy subjects. Skewing of allergic-specific effctor T cells to a Tr1 phenotype appears to be a critical event

in

successful

allergen-specific

immunotherapy

and

glucocorticoids and β2-agonists treatment. Tr1 suppress Th2 cells and effector cells of allergic inflammation, such as eosinophils, mast cells, basophils, through producing IL-10, and perhaps TGF-β. Understanding of Tr1 may be helpful in developing new strategies for treatment of allergic diseases. 【总页数】7页(269-275)

【关键词】allergic disease, immune dysregulation, interleukin 10, regulatory T cell, type 1 regulatory T cell

【作者】Kui Wu;Yutian Bi;Kun Sun;Changzheng Wang

【作者单位】Department of Respiratory Disease, Daping Hospital, Third Military Medical University, Chongqing 400042, China;Department of Respiratory Disease, Daping Hospital, Third Military Medical University, Chongqing 400042, China;Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China;Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China 【正文语种】中文 【中图分类】R3 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_cellular-molecular-immunology_thesis/0201223934056.html 【相关文献】

1.IL-10-Producing Type 1 Regulatory T Cells and Allergy [J], Kui; Wu; Yutian; Bi; Kun; Sun; Changzheng; Wang

2.IL-10 Gene Modified Dendritic Cells Inhibit T Helper Type 1-Mediated Alloimmune Responses and Promote Immunological Tolerance in Diabetes [J], Huifen Zhu; Wenhong Qiu; Ping Lei; Wei Zhou; Xue Wen; Fengrong He; Li Li; Hong Dai; Guanxin Shen; Feili Gong

3.IL-10 Gene Modified Dendritic Cells Inhibit T Helper Type 1-Mediated Alloimmune Responses and Promote Immunological Tolerance in Diabetes [J], Huifen Zhu; Feili Gong; Wenhong Qiu; Ping Lei; Wei

Zhou; Xue Wen; Fengrong He; Li Li; Hong Dai; Guanxin Shen

4.A new effect of IL-4 on human γδ T cells: promoting regulatory Vδ1 T cells via IL-10 production and inhibiting function of Vδ2 T cells [J], Yujia Mao; Shanshan Yin; Jianmin Zhang; Yu Hu; Bo Huang; Lianxian Cui; Ning Kang

5.CD4＋ T cells from behcet patients produce high levels of IL-17 [J], Wei Chi; Sheng Zhou; Peizeng Yang; Lina Chen

以上内容为文献基本信息，获取文献全文请下载