Factors influencing improvement of visual field after trans-sphenoidal resection of pituit

Factors influencing improvement of visual field after trans-sphenoidal resection of pituitary macroadenomas:a retrospective cohort study

Fen-Fen Yu; Li-Li Chen; Yi-Hua Su; Li-Hun Huo; Xian-Xuan Lin; Rui-Duan Liao

【期刊名称】《《国际眼科杂志：英文版》》 【年(卷),期】2015(000)006

【摘要】AIM: To investigate the influencing factors of visual field improvement

after

trans-sphenoidal

resection

of

pituitary

macroadenomas.·METHODS: This retrospective cohort study included 201 patients(366 eyes) with visual field defect induced by pituitary macroadenomas. All of them were treated with trans-sphenoidal surgery. Ophthalmologic evaluation,best-corrected visual acuity(BCVA), and visual field examination were performed before and 3mo after surgery. BCVA, visual field defect index mean deviation(MD), duration of symptoms, age, sex, and volume of tumors were compared. Expression of vascular endothelial growth factor(VEGF) and Ki-67 of tumor tissue were detected by immunohistochemical technique.·RESULTS: The mean age of patients was 44.23±1.29 y.Ninety-three patients were female and 108 were male.The mean tumor volume was 14.36 ±6.23 cm~3. The mean duration of preoperative symptoms was 11.50 ±0.88 mo.Mean preoperative MD was-17.50 ±0.82 d B. Mean Preoperative visual acuity was 0.64 ±0.04. Postoperative visual field improved in 270(73.77%) eyes,