牛蒡子苷元对大鼠和家兔的胚胎-胎仔发育毒性研究
王恩力;董方;刘忠;姚景春
【期刊名称】《中文科技资料目录-中草药》 【年(卷),期】2017(040)003
【摘要】Objective To provide a reference for drug development of Arctigenin,the study is designed to evaluate the developmental toxicities of Arctigenin on embryo-fetal of rats and rabbits.Methods Totally 100 fertilized rats were divided randomly into vehicle control group,Arctigenin 4,16,and 64 mg/kg groups,and 72 fertilized rabbits were divided randomly into vehicle control group,Arctigenin 4,10,and 25 mg/kg groups.Animals were ip administered with Arctigenin from day 6 of pregnancy (GD6) once daily,rats were treated until GD15 and sacrificed on GD20,while rabbits were treated until GD18 and sacrificed on GD29.The clinical manifestation of animals was observed every day during test period,feed take and bodyweight were detected regularly.Corpora lutea number,implantation number,and living fetus number were counted.Lengths of fetus Crown-Rump and tail were measured and the appearance,skeleton,and viscera of fetus were detected.Results With the exception of inflammation caused by treated method,no apparent toxic reaction in pregnant animals was shown in all groups.Compared with vehicle control,rats and rabbits treated with Arctigenin had no abnormal change on maternal pregnancy
相关推荐：
loading