Product Data?Sheet
Thymalfasin
Cat. No.:CAS No.:分?式:分?量:Sequence:
HY-P009162304-98-7C???H???N??O??3108.28
N-acetyl-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn
Sequence Shortening:Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN作?靶点:作?通路:储存?式:
OthersOthersPowderIn solvent
-80°C-20°C-80°C-20°C
2 years1 year6 months1 month
Inhibitors?Agonists?Screening Libraries溶解性数据
体外实验
H2O : 0.3 mg/mL (0.10 mM; Need ultrasonic and warming)
BIOLOGICAL ACTIVITY
?物活性体外研究
Thymalfasin (thymosin-alpha 1) 是?个免疫调节化合物，能够提? Thl 的免疫应答。
Thymalfasin has been shown to have efficacy in multiple experimental models of immune dysfunction, mainly, infectious diseases such as hepatitis (woodchuck) and influenza (mouse), and cancer such as melanoma (mouse) and colorectal carcinoma (rat) where thymalfasin has shown antitumor effects[2].
体内研究
Thymalfasin has been shown to have efficacy in multiple experimental models of immune dysfunction, mainly, infectious diseases such as hepatitis (woodchuck) and influenza (mouse), and cancer such as melanoma (mouse) and colorectal carcinoma (rat) where thymalfasin has shown antitumor effects[2].
REFERENCES
[1].?Lao X et al. A modified thymosin alpha 1 inhibits the growth of breast cancer both in vitro and in vivo: suppressment of cell proliferation, inducible cell apoptosis and enhancement of targeted anticancer effects. Apoptosis. 2015 Oct;20(10):1307-20.
[2].?Sjogren MH et al. Thymalfasin: an immune system enhancer for the treatment of liver disease. J Gastroenterol Hepatol. 2004 Dec;19(12):S69-72.
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