新生儿小时经皮胆红素百分位曲线图预测高胆红素血症价值的多中心

新生儿小时经皮胆红素百分位曲线图预测高胆红素血症价

值的多中心临床研究

新生儿高胆红素血症临床研究协作组

【期刊名称】《中华儿科杂志》 【年(卷),期】2015(053)011

【摘要】Objective To assess the predictive value of hour-specific transcutaneous bilirubin (TcB) nomogram for subsequent neonatal hyperbilirubinemia.Method Thirteen tertiary class-A hospitals (including two hospitals respectively in the northeastern, northern, eastern, south, northwest, southwestern regions of China, and one in central region) participated in this multicenter study between January 1 and December 31, 2013.All TcB measurements were obtained from healthy term and near-term newborns (gestational age ≥35 weeks, birth weight ≥ 2 000 g) by the JM-103 bilirubinometer between 0 and 168 postnatal hours.Developed an hour-specific TcB bilirubin nomogram with these data.Newborns were divided into 4 groups based on the predischarge bilirubin \ P40-P75 , ＞ P75-P95 , and ＞ P95 as low, low-intermediate, high-intermediate and high risk zones on the hour-specific

bilirubin

nomogram)

to

predict

subsequent

hyperbilirubinemia.Selected bilirubin measurements of three time quantums (25-48 h,49-72 h, 73-96 h) as a predictor for the respective danger zone, and adopted ROC curve to assess the predictive ability of