多发性肌炎和皮肌炎患者血清B细胞活化因子水平及其临床意义

多发性肌炎和皮肌炎患者血清B细胞活化因子水平及其临

床意义

彭清林;谢瑶;张荣富;舒晓明;王国春

【期刊名称】《中华内科杂志》 【年(卷),期】2012(051)003

【摘要】目的 探讨多发性肌炎(PM)、皮肌炎(DM)患者血清中B细胞活化因子(BAFF)水平及其临床意义.方法 ELISA检测28例PM患者、30例DM患者、25例健康人血清BAFF水平,ELISA检测PM、DM患者血清中抗Jo-1抗体浓度.结果 PM和DM患者血清BAFF水平[(2964±3743)ng/L]高于健康人[(832±170)ng/L,P=0.000],但PM患者[(2886±3901)ng/L]和DM患者[(3036±3654)ng/L]间血清BAFF水平差异无统计学意义(P＞0.05).合并间质性肺疾病(ILD)的PM和DM患者血清BAFF水平[(4540±4576)ng/L]显著高于未合并ILD者[(1153 ±430)ng/L,P =0.000]和健康人(P =0.000).抗核抗体(ANA)阳性者[(3807 ±4914)ng/L]血清BAFF水平高于ANA阴性者[(2369±2548)ng/L,P=0.003].抗Jo-1抗体阳性者血清BAFF水平与抗Jo-1抗体浓度呈正相关(r =0.799,P=0.006).结论 PM、DM患者血清BAFF水平升高,可能参与PM、DM的发病机制.检测患者血清BAFF浓度对疾病的诊断与治疗具有一定意义.%Objectives To investigate serum levels of B cell activating factor(BAFF)in

Chinese

patients

with

polymyositis(PM)or

dermatomyositis(DM),and analyze the correlation of BAFF with autoantibodies and clinical phenotypes.Methods Serum BAFF levels of 28 PM patients and 30 DM patients(study group),and 25 matched