Hans Journal of Biomedicine 生物医学, 2019, 9(2), 70-80
Published Online April 2019 in Hans. http://www.hanspub.org/journal/hjbm https://doi.org/10.12677/hjbm.2019.92011
Effect of Bifidobacterium lactis GKK2 on OVA-Induced Asthmatic Mice
Yu-Hsin Hou1, Shih-Wei Lin1, Chang Zhao2, Hung-Chieh Lu2, Yen-Lien Chen1, Wen-Hsin Lin3, Chin-Chu Chen1,4,5,6*
12
Grape King Bio Ltd., Taoyuan Taiwan
Shanghai Grape King Enterprise Co., Ltd., Shanghai 3
School of Pharmacy, China Medical University, Taichung Taiwan 4
Institute of Food Science and Technology, National Taiwan University, Taipei Taiwan 5
Department of Food Science, Nutrition, and Nutraceutical Biotechnology, Shih Chien University, Taipei Taiwan 6
Bioscience Technology, Chung Yuan Christian University, Taoyuan Taiwan
ndthnd
Received: Apr. 2, 2019; accepted: Apr. 15, 2019; published: Apr. 22, 2019
Abstract
Asthma is a chronic bronchitis that can cause respiratory failure and even lead to life-threatening in severe conditions. The present study is to evaluate Bifidobacterium lactis GKK2 ability in im-proving allergic problems and regulating related allergic factors in a mouse model of OVA-allergic asthma. Balb/c mice were divided into four groups as follows: control group, OVA-allergic asthma group, OVA-allergic asthma with GKK2-100 group (0.123 mg/day/kg) and OVA-allergic asthma with GKK2-300 group (0.41 mg/day/kg). Results showed that after OVA-allergic asthma mice were given both doses of B. lactis GKK2, their airway resistance, eosinophil, and OVA-specific IgE were significantly lower than those of OVA-induced asthmatic mice. In the IFN-γ and IgG2a, administra-tion of B. lactis GKK2 can also effectively increase the content of IFN-γ and IgG2a in OVA-induced asthmatic mice and reduce allergic reactions.
Keywords
Bifidobacterium lactis GKK2, Probiotics, Allergic Asthma
乳双岐杆菌GKK2对OVA诱导气喘小鼠之影响
侯毓欣1，林诗伟1，赵 敞2，卢弘捷2，陈炎炼1，林文鑫3，陈劲初1,4,5,6*
12
葡萄王生技股份有限公司，台湾 桃园 上海葡萄王企业有限公司，上海 3
中国医药大学药学系，台湾 台中
*
通讯作者。
文章引用: 侯毓欣, 林诗伟, 赵敞, 卢弘捷, 陈炎炼, 林文鑫, 陈劲初. 乳双岐杆菌GKK2对OVA诱导气喘小鼠之影响[J]. 生物医学, 2019, 9(2): 70-80. DOI: 10.12677/hjbm.2019.92011
相关推荐：
loading