CYTOSOLIC FLUORESCENT ION INDICATORS

CYTOSOLIC FLUORESCENT ION INDICATORS

申请(专利)号： EP20110827351

专利号： EP2619199A4 主分类号： C07D413/14 申请权利人： ASANTE

RESEARCH, LLC 公开国代码： EP 优先权国家： US

摘 要：

Novel fluorophores for fluorescent ion indicators incorporate water-solubilizing functional groups. These fluorophores enable visible-wavelength analysis of ion concentrations with chelators that are insoluble or poorly soluble in water. A green version of the fluorophore

comprises a putative fluorescein with carboxylate appendages. An orange version of the fluorophore comprises a putative rhodamine, also with carboxylate appendages. Attaching the fluorophore to a 12-crown-4, a 15-crown-5, a 18-crown-6, a 21-crown-7, or a 24-crown-8 produces lithium, sodium, potassium, rubidium, and cesium indicator families, respectively. Attaching the fluorophore to diaza [1,1,1], [1,1,2], [1,2,2], [2,2,2], [2,2,3], [2,3,3], or [3,3,3] cryptands

produces more selective lithium, sodium, potassium, rubidium, and cesium

indicator families, respectively. Attaching the fluorophore to BAPTA, APTRA, or

申请日： 2011-09-20 公开公告日： 2015-08-12

分类号： C07D413/14;

G01N33/58 发明设计人： MINTA, AKWASI;

ESCAMILLA,

PEDRO, ROGELIO 申请国代码： EP

优先权： 20100920 US

38469510; 20110920 US 2011052353

摘 要 附 图：

half- BAPTA or their analogs produces new calcium, magnesium, and other metal ions indicator families that strongly resist leakage from the cell. 主权项：

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