结缔组织病累及神经系统临床表现及治疗

结缔组织病累及神经系统临床表现及治疗

戚晓昆;董秦雯

【期刊名称】《中国实用内科杂志》 【年(卷),期】2012(032)011

【摘要】Connective tissue disease (CTD) , subordinated to the rheumatic diseases, belongs to the non-organ specific autoimmune disease which can involve single or multiple systems hence the presence of different clinical manifestations. So far,the mechanism of CTD is still uncertain. Many studies showed that CTD was correlated with its antibodies and T-cell mediated lesions,with the pathological basis of chronic inflammation in vessels and connective tissues. CTD can involve the brain,meninges,spinal cord,cranial and peripheral nerves,with various clinical manifestations. Efficacy could be found in many CTDs after treatment of corticosleroids and immunosuppressive agents. Nevertheless,many symptoms couldn't be totally relieved hence the further study for the new treatment.%结缔组织病是风湿性疾病中的一大类,属非器官特异性的自身免疫疾病,可累及单个或多个系统出现不同的临床表现其机制目前尚不明确,多数研究表明与自身抗体及T细胞介导有关,以血管和结缔组织的慢性炎症为病理基础结缔组织病可累及大脑、脑膜、脊髓、颅神经及神经末梢等神经系统,有多种临床表现.多数结缔组织病经皮质类固醇及免疫抑制剂治疗后有效,但症状多不能完全缓解,新的治疗方案仍有待进一步研究. 【总页数】4页(842-845)