56例早期结直肠癌内镜非治愈切除患者预后危险因素分析

56例早期结直肠癌内镜非治愈切除患者预后危险因素分析

王瑞刚;张月明;窦利州;刘勇;贺舜;刘晓;于新颖;王贵齐

【期刊名称】《中华胃肠外科杂志》 【年(卷),期】2017(020)008

【摘要】Objective To explore the risk factors contributing to the progression-free survival rate of patients undergoing endoscopic non-curative resection. Methods Clinicopathological data of patients with early colorectal carcinoma and intraepithelial neoplasia undergoing endoscopic resection in our department from January 2009 to January 2015 were collected. Associated factors affecting the progression-free survival rate of the early colorectal carcinoma after endoscopic non-curative resection were analyzed. Any of the following conditions was defined as endoscopic non-curative resection: (1) positive lateral or vertical cutting margin; (2) submucosa invasion depth ≥1000 μm; (3) vascular or lymphatic invasion; (4) low differentiation, including signet ring cell carcinoma or mucinous adenocarcinoma; (5) high grade tumor budding. Results Clinicopathological data of 840 cases were collected. According to China′s Endoscopic Screening , Diagnosis and Treatment Guidelines for Early Colorectal Cancer, 56 (56/840, 6.7％) cases were defined as the non-curative resection,the metastasis or recurrence rate was 14.3％(8/56), 3-year progression-free survival rate was 85.7％(48/56), and 3-year overall survival rate was 94.6％(53/56). Univariate