纤溶酶原激活物抑制物-1基因-844G→A多态性与不稳定
心绞痛的关系
路雅茹;秦勤;毛用敏;李广平;赵炳让
【期刊名称】《实用医学杂志》 【年(卷),期】2012(028)008
【摘要】Objective To investigate the relatione relationship between level of PAI-1 antigen,its geng promoter -844G->A polymorphism and unstable angina pectoris. Methods 121 patients with unstable angina pectoris (UAP group) and 108 patients with angiography-proved no stenosis (control group) were studied. The level of PAI-1 antigen was measured by ELISA. The specific DNA segment of PAI-1 was amplified by PCR, and incised by endonuclease XhoI.The genotype of PAI-1 gene promoter-844 site was confirmed by Agarose Electrophoresis. Results The level of PAI-1 antigen in UAP group was significantly higher than that in control group (68.15 ± 45.29) jig/Las (53.39 ± 20.62) |xg/L, P< 0.001). The level of PAI-1 antigen showed a positive correlation with Glu, TC and LDL(r = 0.147,0.15,0.144, P < 0.05). Frequency of A,G allele is 0.4,0.6,there was no important difference in genotype frequency of AA,AG,GG in both groups. A allele is associated with higher level of PAI-1 antigen. Conclusion High level of PAI-1 antigen is a risk factor for UAP.PAI-1 gene Promoter-844G->A polymorphism has no relationship with the occurrence of UAP,but there is higher level of PAI-1 antigen in
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