重度子痫前期患者胎盘组织TGF-β1及MMP-9的表达及意义

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重度子痫前期患者胎盘组织TGF-β1及MMP-9的表达及

意义

赵祖英;梁劲劲;陆洁清

【期刊名称】《中国计划生育和妇产科》【年(卷),期】2017(009)010

【摘要】Objective To study the expression and clinical significance of transforming growth factor -β1(TGF -β1) and matrix metalloproteinase-9 (MMP-9) in placenta of patients with severe preeclampsia. Methods The expression of TGF-β1and MMP-9 in placenta of 50 normal pregnant women and 60 cases of preeclampsia(25 cases were mild and 35 cases were severe) were analyzed by Western blot. Including 15 cases of early-onset mild preeclampsia,10 cases of late-onset mild preeclampsia;18 cases of early-onset severe preeclampsia and 17 cases of late -onset severe preeclampsia. Results The expression of TGF -β1was significantly increased in the stage of severe preeclampsia,and the expression of MMP-9 was significantly decreased.Compared with mild preeclampsia group and normal pregnancy group,the differences were statistically significant(P<0.05).The expression of TGF-β1in placental tissue was negatively correlated with the expression of MMP-9 (P<0.05). The expression of TGF-β1and MMP-9 in early-onset and late-onset group of patients with preeclampsia were compared and differences between the two were statistically significant(P <0.05). Conclusion The abnormal

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