dear editor,
we would like to submit the enclosed manuscript entitled \potassium channels in midbrain dopaminergic neurons\which we wish to be considered for publication in nature neuroscience. gdnf has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic
neurons, which are degenerated in parkinson?s disease. in this paper, we report an unexpected, acute effect of gdnf on a-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. further, we show that gdnf regulates the k+ channels through a mechanism that involves activation of map kinase. thus, this study has revealed, for the first time, an acute modulation of ion channels by gdnf. our findings challenge the classic view of gdnf as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of gdnf is to regulate neuronal excitability, and consequently dopamine release. these results may also have implications in the treatment of parkinson?s disease.
due to a direct petition and conflict of interest, we request that drs. xxx of harvard univ., and yy of yale univ. not be considered as reviewers. with thanks for your consideration, i am
sincerely yours, （四） dear **.
we would like to submit the enclosed manuscript entitled \*** \**journal.
we believe that two aspects of this manuscript will make it interesting to general readers of **journal. first, ***. second, ***. further, ***.
thank you very much your considering our manuscript for potential publication. i'm looking forward to hearing from you soon.
best wishes. （五）
to: sola chief editor
division of geoenvironmental sciences university of tsukuba tsukuba 305-8572, japan
e-mail: sola@sakura..tsukuba.ac.jp dear sirs,
i am sending herewith a copy of the manuscript, which i would like to submit to sola, the electronic journal of the meteorological society of japan. the paper is entitled:
energy spectrum proportional to the squared phase speed of rossby modes in the general circulation of the atmosphere by h. l. tanaka, yasushi watarai, and takahiro kanda. copy of the abstract:
in this study, energy spectrum of the large-scale atmospheric motions is examined in the framework of the 3d normal mode deposition. the horizontal scale of disturbance is measured by the phase speed of a rossby mode c. aording to the analysis result for the barotropic ponent of the atmosphere, we obtain a characteristic energy spectrum with distinct slopes for the turbulence and wave regimes separated by the spherical rhines speed. in order to explain the observational finding that the energy
spectrum is proportional to c^2, we put forward a hypothesis based on the criterion of rossby wave breaking such that the local meridional gradient of potential vorticity bees negative,
dq/dy < 0, somewhere in the domain. with a constant m describing a total mass of the atmosphere for unit area, we have shown that the barotropic energy spectrum of the general circulation e can be represented as e=mc^2. corresponding author: dr. hiroshi l. tanaka
division of geoenvironmental sciences university of tsukuba tsukuba 305-8572, japan tel: +81-29-853-4502 fax: +81-29-853-6879
e-mail: tanaka@sakura..tsukuba.ac.jp
i hereby certify that this paper consists of original, unpublished work which is not under consideration for publication elsewhere. desired editors in charge:
kimoto, masahide university of tokyo mak, mankin university of illinois five potential reviewers: name-1, e-mail address-1 name-2, e-mail address-2 name-3, e-mail address-3
name-4, e-mail address-4 name-5, e-mail address-5
the original manuscript and figures will be transferred, following the instruction by the editorial mittee when the paper is aepted. i hope your favorable consideration for publication to sola. sincerely, hiroshi l. tanaka
attachment: pdf file of the manuscript. april 13,xx p.o. box 36 tsinghua university bei * g,china 100084 dear sir/madam:
your advertisement for a work maintenance engineer in the april 10 student daily interested me bacause the position that you described sounds exactly like the kind of job i am seeking. aording to the advertisement ,your position requires top university,bachelor or above in puter science or equivalent field and proficient in windows nt4.0 and linux system. i feel that i am
petent to meet the requirements. i will be graduating from graduate school of tsinghua university this year with a m.s.
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