电磁脉冲对大鼠血脑屏障通透性及紧密连接蛋白的影响

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邱联波;郭国祯;丁桂荣;张亚美;周艳;王晓武;李康樗;徐胜龙;谭娟;周家兴

【期刊名称】《中华劳动卫生职业病杂志》【年(卷),期】2009(027)009

【摘要】Objective To study the effect of electromagnetic pulse(EMP)on the permeability of blood-brain barrier, tight junction (TJ)-associated protein expression and localization in rats. Methods 66 male SD rats, weighing (200～250) g, were sham or whole-body exposed to EMP at 200 kV/m for 200 pulses. The repetition rate was 1 Hz. The permeability of the blood-brain barrier in rats was assessed by albumin im-munohistochemistry. The expression of typical tight junction protein ZO-1 and occludin in both cerebral cortex homogenate and cerebral cortex microvessel homogenate was analyzed by the Western blotting and the distri-bution of ZO-1 and oceludin was examined by immunofluoreseenee microscopy. Results In the sham expo-sure rats, no brain capillaries showed albumin leakage, at 0.5 h after 200 kV/m EMP exposure for 200 pulses; a few brain capillaries with extravasated serum albumin was found, with the time extended, the number of brain capillaries with extravasated serum albumin increased, and reached the peak at 3 h, then began to recover at 6 h. In addition, no change in the distribution of the oeeludin was found after EMP exposure. Total occludin ex-pression had no significant change compared with the

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