植酸作用机制- Medchemexpress- MCE中国

Product Data?SheetPhytic acidCat. No.:CAS No.:分?式:分?量:作?靶点:作?通路:储存?式:HY-N081483-86-3C?H??O??P?660.04Xanthine Oxidase; Endogenous MetaboliteMetabolic Enzyme/ProteasePure formIn solvent-20°C4°C-80°C-20°C3 years2 years6 months1 monthInhibitors?Agonists?Screening Libraries溶解性数据体外实验H2O : 100 mg/mL (151.51 mM; Need ultrasonic)Mass1 mg5 mg10 mgSolventConcentration制备储备液1 mM5 mM10 mM1.5151 mL0.3030 mL0.1515 mL7.5753 mL1.5151 mL0.7575 mL15.1506 mL3.0301 mL1.5151 mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；?旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存?式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个?内使?，-20°C 储存时，请在 1 个?内使?。BIOLOGICAL ACTIVITY?物活性Phytic acid 是种?和?粒的磷储存化合物。Phytic acid 被称为?品抑制剂，具有很强的螯合多价?属离?的能?，特别是锌，钙，铁和蛋?质残留物。Phytic acid 抑制超氧化物来源黄嘌呤氧化酶 (XO) 并具有抗氧化，神经保护以及抗炎作?[1][2][3][4]。IC?? & TargetHuman Endogenous Metabolite(批量添加)体外研究Phytic acid (myo-Inositol) inhibits the formation of uric acid from xanthine with an IC50 of about 30 mM. The generation of the superoxide is greatly affected by phytic acid; the IC50 is about 6 mM, indicating that the superoxide generating domain of XO is more sensitive to phytic acid[3].Page 1 of 2 www.MedChemExpress.cn

PROTOCOL

Animal

Administration [4]

Mice: MPTP (20 mg/kg/day, i.p.) is administrated for 5 days and animals are killed at 7 days later. Phytic acid (30 mg/kg/day, i.p.) or normalsaline is injected 4 days before MPTP administration and con-tinued until mice are killed, reaching a total treatment period of16 days[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

REFERENCES

[1].?Zhou JR, et al. Phytic acid in health and disease. Crit Rev Food Sci Nutr. 1995 Nov;35(6):495-508.

[2].?Gupta RK, et al. Reduction of phytic acid and enhancement of bioavailable micronutrients in food grains. J Food Sci Technol. 2015 Feb;52(2):676-84.[3].?Muraoka S, et al. Inhibition of xanthine oxidase by phytic acid and its antioxidative action. Life Sci. 2004 Feb 13;74(13):1691-700.

[4].?Lv Y, et al. Phytic acid attenuates inflammatory responses and the levels of NF-κB and p-ERK in MPTP-induced Parkinson's disease model of mice. Neurosci Lett. 2015 Jun 15;597:132-6.

McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.

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