不同麻醉剂对MECT抑郁患者血压及认知功能的影响

不同麻醉剂对MECT抑郁患者血压及认知功能的影响

杨海燕;曾祥刚;万红

【期刊名称】《中国药业》 【年(卷),期】2013(022)012

【摘要】目的 观察无抽搐电休克治疗(MECT)中丙泊酚与硫喷妥钠对抑郁患者血压及认知功能的影响.方法 将56例接受MECT治疗的抑郁症患者随机分为两组,在MECT时分别使用硫喷妥钠或丙泊酚诱导麻醉,疗程为8次,在治疗前和治疗结束后5 min记录患者心率(HR)、平均动脉压(MAP),治疗前和疗程结束1周后进行汉密顿抑郁量表(HAMD)、威斯康星卡片分类(WCST)、连续作业测验(CPT)、修订韦氏成人智力量表(WAIS-RC)测查评定.结果 硫喷妥钠组MECT后MAP高于丙泊酚组(P＜0.01),两组疗程结束1周后HAMD分均比治疗前降低(P＜0.01),WCST,CPT,WAIS-RC评分比较无统计学差异(P＞0.05).结论 丙泊酚用于MECT治疗麻醉诱导时,对患者认知功能无明显影响,同时对MAP影响小,可作为MECT首选麻醉药.%Objective To investigate the effects of thiopental sodium and propofol on BP and the cognitive function in the patients with depression during the modified electroconvulsive therapy(MECT).Methods 56 patients with major depression treated by MECT were randomly divided into 2 group and performed the induced anesthesia with thiopental sodium and propofol respectively during MECT.The course of treatment was 8 times.The heart rate(HR) and mean arterial pressure(MAP) were recorded before therapy and at 5 min after MECT.Depression and the cognitive function were evaluated by using

the Hamilton Depression Scale(HAMD),the Wisconsin Card Sorting Test(WCST),the Continuous Performance Test(CPT) and the Wechsler Adult Intelligence Scale-Revised China(WAIS-RC) before treatment and in 1 week after treatment.Results MAP in the thiopental sodium group was significantly higher than that in the propofol group(P＜0.01).The HAMD scores in 1 week after therapy in the two groups were significantly decreased compare with before therapy(P ＜ 0.01).There was no statistical differences in the WCST,CPT,WAIS-RC scores(P ＞ 0.05).Conclusion Propofol has no obvious influence on the cognition function and little influence on MAP,and can serve as the first choice of anaesthetic for the induction of MECT. 【总页数】2页(72-73)

【关键词】硫喷妥钠;丙泊酚;无抽搐电休克治疗;认知功能 【作者】杨海燕;曾祥刚;万红

【作者单位】重庆市精神病院,重庆 400038;重庆市精神卫生中心,重庆 401147;重庆市精神卫生中心,重庆 401147 【正文语种】中文

【中图分类】R969.4;R971+.2 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_china-pharmaceuticals_thesis/0201242794636.html 【相关文献】

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