Management of intracranial invasive olfactory neuroblastoma

Management of intracranial invasive olfactory

neuroblastoma

ZHANG Li-wei;ZHANG Ming-shan;QI Ji;ZHANG Jun-ting;LI Gui-lin;LUO Lin;WANG Zhong-cheng

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2007(120)003

【摘要】Background Olfactory neuroblastoma (ONB) is a rare tumor that often arise from the nasal cavity. The aim of this study was to investigate the clinical characteristics and treatments of intracranial invasive ONB.Methods Between July 2001 and August 2005, 5 patients with intracranial invasive ONB were treated in our department. Their clinical features, radiological and pathological characteristics, and surgical treatments were analyzed.Among the 5 patients, 1 received transnasal biopsy, and 4 were operated through the transfrontal or extended bifrontal approaches to reconstruct the skull base. After the operation, all the patients received radiotherapy, and one received chemotherapy. They were followed up for 6 to 45 months.Results The ONB was resected totally in the 4 patients. In all the patients, nasal obstruction was alleviated without cerebrospinal fluid leakage. The visual acuity was improved in 3 patients, who had a decreased visual acuity before the operation. Two patients had metastasis into the lumbosacral spinal canal 6 and 8 months after the operation, one of

them received a second operation and the other died.Concluslon ONB has no specific symptoms. Intracranial ONB should be resected as far as possible, and treated by radiotherapy afterthe operation. 【总页数】4页(224-227)

【关键词】esthesioneuroblastoma, olfactory;therapy

【作者】ZHANG Li-wei;ZHANG Ming-shan;QI Ji;ZHANG Jun-ting;LI Gui-lin;LUO Lin;WANG Zhong-cheng

【作者单位】Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;Beijing Institute of Neurosurgery, Capital Medical University,Beijing 100050, China;Beijing Institute of Neurosurgery, Capital Medical University,Beijing 100050, China;Beijing Institute of Neurosurgery, Capital Medical University,Beijing 100050, China 【正文语种】中文 【中图分类】R3 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-medical-journal_thesis/0201254771536.html

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