熊果酸的药动学研究进展

熊果酸的药动学研究进展

张明发;沈雅琴

【期刊名称】《中文科技资料目录-中草药》 【年(卷),期】2018(041)001

【摘要】熊果酸具有广泛的药理作用,包括抗炎、抗变态反应,抗肿瘤,保护心、血管、肝、肾、肺,抗糖尿病、调血脂抗肥胖,抗动脉粥样硬化等.但是其口服的生物利用度低,通过被动扩散被肠道吸收;将熊果酸制成分散体制剂能提高溶出度和生物利用度,且能浓集于肝脏,有利于治疗肝部疾病.综述熊果酸的药动学参数、体内过程和熊果酸分散体的药动学特征,总结其药动学研究进展,为合理用药提供参考.%Ursolic acid has a widespread pharmacologic effect,including anti-inflammation,anti-allergy,antitumor,protection vessel,liver,kidney,lung,antidiabetes,lipidemic obesity,antiatherosclerosis,anti-hepatic

of

heart,blood and

anti-and

regulation steatosis

fibrosis,etc.Bioavailability of ursolic acid by oral administration is low since it is absorbed by intestine through passive diffusion.Ursolic acid dispersion preparation can increase its solubility and bioavailability,and concentrate on liver to help treat for hepatic disease.In this paper,the pharmacokinetie parameters,the process ofursolic acid in vivo,and the pharmacokinetic feature of ursolic acid dispersion are reviewed,and its research advance on pharmacokinetics is summarized,in order to provide a reference for rational utilization ofursolic acid. 【总页数】5页(169-173)