Prevalence and hematological indicators of G6PD deficiency in malaria-infected patients

Prevalence and hematological indicators of G6PD

deficiency in malaria-infected patients

Manas Kotepui;Kwuntida Uthaisar;Bhukdee PhunPhuech;Nuoil Phiwklam

【期刊名称】《贫困所致传染病（英文）》 【年(卷),期】2016(005)002

【摘要】Background:This study aimed to evaluate the prevalence and alteration of hematological parameters in malaria patients with a glucose-6-phosphate dehydrogenase (G6PD) deficiency,in the western region of Thailand,an endemic region for malaria.Methods:Data about patients with malaria hospitalized between 2013 and 2015 were collected.Clinical and sociodemographic characteristics such as age and gender,diagnosis on admission,and parasitological results were mined from medical records of the laboratory unit of the Phop Phra Hospital in Tak Province,Thailand.Venous blood samples were collected at the time of admission to hospital to determine G6PD deficiency by fluorescence spot test and detect malaria parasites by thick and thin film examination.Other data such as complete blood count and parasite density were also collected and analyzed.Results:Among the 245 malaria cases,28 (11.4 ％) were diagnosed as Plasmodium falciparum infections and 217 cases (88.6 ％) were diagnosed as P.vivax infections.Seventeen (6.9 ％) patients had a G6PD deficiency and 228 (93.1％) patients did not have a G6PD deficiency.Prevalence of male patients with G6PD

deficiency was higher than that of female patients (P ＜ 0.05,OR =5.167).Among the patients with a G6PD deficiency,two (11.8 ％) were infected with P.falciparum,while the remaining were infected with P.vivax.Malaria patients with a G6PD deficiency have higher monocyte counts (0.6 × 103/μL) than those without a G6PD deficiency (0.33 × 103/μL) (P＜ 0.05,OR=5.167).Univariate and multivariate analyses also confirmed that malaria patients with a G6PD deficiency have high monocyte counts.The association between G6PD status and monocyte counts

was

independent

of

age,gender,nationality,Plasmodium

species,and parasite density (P ＜ 0.005).Conclusion:This study showed a prevalence of G6PD deficiency in a malaria-endemic area.This study also supported the assertion that patients with G6PD-deficient red blood cells had no protection against the P.falciparum infection.In addition,malaria patients with a G6PD deficiency had higher monocyte counts than those without a G6PD deficiency.These findings will help to recognize and diagnose malaria patients with a G6PD deficiency,as well as to identify the risks and protective factors against malaria in endemic areas.

【总页数】6页(39-44) 【关键词】

【作者】Manas Kotepui;Kwuntida Uthaisar;Bhukdee PhunPhuech;Nuoil Phiwklam

【作者单位】Medical Technology Program,School of Allied Health Sciences and Public Health,Walailak University,Nakhon Si Thammarat 80161,Thailand;Medical Technology Program,School of Allied Health Sciences and Public Health,Walailak University,Nakhon Si Thammarat 80161,Thailand;Medical Hospital,Phop

Phra

Technology

Laboratory,Phop

Phra

District,Tak Province 63160,Thailand;Medical

Technology Laboratory,Phop Phra Hospital,Phop Phra District,Tak Province 63160,Thailand 【正文语种】英文 【中图分类】 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_infectious-diseases-caused-poverty-english_thesis/0201243956788.html 【相关文献】

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