NF-kB 启动因子(6)

生命科学

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Figure3InhibitionofhepatocyteNF-kBactivityin uencesneitherhepatitisnordevelopmentofthepremalignantfeaturesinMdr2-knockoutmice.a,H&E-stainedsectionsof4-month-oldwild-type,knockoutanddoublemutantmice.b,SerumALTlevels,averagenumberofCD3-positivecellsperonehighpower eld(HPF),numberofKi-67-positivehepatocytesper20HPFsandpercentageofhyperploidnuclei.Allbar-graphsindicatemean^s.e.m.c,H&E-stainedsectionsfromliversof7-month-oldmiceoftheindicatedgenotypes,showingcomparabledysplasiaevidentbyarchitecturaldisorganizationandprominentnuclearpleomorphisminbothknockoutsanddoublemutants,incontrasttothenormalnucleiinwildtypes.Allscalebars,100mm.m.o.,monthsold;DM,doublemutant.

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