板蓝根药材提取车间工艺设计

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哈尔滨理工大学学士学位论文 年处理2000吨板蓝根药材提取车间工艺设计

摘要

板蓝根是我国一味传统中药，是大青叶、菘蓝等的干燥茎、根，始载于《神农本草经》，在我国有着悠久的临床治疗历史。板蓝根中可提取出多种化学成份，如:靛蓝、靛玉红、氨基酸、有机酸等有效物质，能够有效防治流行性乙型肝炎、急慢性肝炎、流行性腮腺炎、骨髓炎等病症，在抗菌、抗病毒、抗免疫系统疾病方面也有着很好疗效。

板蓝根颗粒剂因为其方便有效特点应用较广，本文将结合国家GMP车间设计相关规定，设计板蓝根提取车间。主要对板蓝根颗粒剂的前处理和提取工艺进行讨论优化：前处理的工艺选择，水提醇沉与醇提水沉的优缺点，用正交试验法优化选出板蓝根提取的最佳工艺，设计提取车间工艺流程。按照设计任务书给出数据进行物料衡算与热量衡算，计算车间的生产处理能力，根据计算结果进行设备选型，使满足车间生产要求。最后进行车间平面布置，车间将按照传统四层设计。车间的辅助设施设计也要符合国家规定，三废排出、安全防护等方面也会根据车间特点进行相应布局。

关键词 板蓝根；提取；浓缩；车间设计

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哈尔滨理工大学学士学位论文 Years processing 2000 tons of root of medicinal materials extraction workshops engineering

Abstract

Root of the SARS virus has good why the curative effect? Why in Shanghai armour liver prowled the root when big popular? But times across, root of why influenza can play an important role again? Recently, guangzhou baiyun mountain hutchison whampoa TCM Co., LTD and state medical school first affiliated hospital virus lab reach agreement, will in the medical association member zhong nanshan devoted himself under the guidance of \the parties association study of antibiotic\root of antiviral mechanism. Root of medicine for nearly thousand years of history, has long been widely used in cold, especially the flu prevention, when the virus temperament popular, played the role of big root. However, the action mechanism and the root of the active ingredient in antiviral action still clear. According to expert analysis, root of at least three advantages. One is the application foundation. Baiyun mountain root of particles of market at present rate of 60%, are widely used in many areas are based, is consumer and the doctor's first drug. 2 it is technology accumulation. Yunshan root produced in the country's largest medicinal herbs first base, and the GAP of the fingerprint of using international advanced technology, and strictly control product quality. Third, and most important, is scientific research strength. According to introducing, this study will be in the international first-class virus expert academician nanbert zhong, under the guidance of Singapore studies abroad by just returning from a ZhangWeiDong of a research dr in baiyun mountain root for quality object, to particle flu virus, herpes virus virus for dozens of in vitro and in vivo from immunology, experiment research, discusses the root of such party irological antiviral mechanism. Guangzhou baiyun mountain hutchison whampoa Chinese medicine academy, said dr CengLingJie modern, the study not only help to further perfect blue root production link, improve product quality, still can let more people understanding Chinese root, which helps to explore international market.

Keywords Root; Antiviral; Extraction; Workshop design

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哈尔滨理工大学学士学位论文

目录

摘要 ...................................................................................................................... I Abstract ............................................................................................................... II

第1章 绪论 ........................................................................................................ 1 1.1 板蓝根的来源 ........................................................................................... 1 1.2 板蓝根的化学成分 ................................................................................... 1 1.3 板蓝根的药理作用 ................................................................................... 1 1.3.1 抗肿瘤作用 ........................................................................................ 1 1.3.2 抗菌作用 ............................................................................................ 2 1.3.3 抗病毒作用 ........................................................................................ 2 1.4 中药提取方法与应用 ............................................................................... 3 1.5 主要设计内容 ........................................................................................... 4 第2章 生产工艺设计 ........................................................................................ 6 2.1 前处理 ....................................................................................................... 6 2.1.1 风选 .................................................................................................... 6 2.1.2 洗药 .................................................................................................... 6 2.1.3 切片 .................................................................................................... 6 2.1.4 投药 .................................................................................................... 6 2.2 药物有效成分的提取与浓缩 ................................................................... 6 2.2.1 提取方法比较 .................................................................................... 6 2.2.2 水提液浓缩 ........................................................................................ 7 2.2.3 醇沉 .................................................................................................... 8 2.3 干燥得浸膏 ............................................................................................... 8 2.4 生产工艺流程 ........................................................................................... 9 2.5 制药场总体设计 ....................................................................................... 9 2.5.1 总体设计原则 .................................................................................. 10 2.5.2 车间布局原则 .................................................................................. 10 2.6 本章小节 ................................................................................................. 11 第3章 物料衡算及设备选型 .......................................................................... 12 3.1 物料衡算 ................................................................................................. 12 3.1.1 生产制度 .......................................................................................... 12 3.1.2 前处理车间物料衡算 ...................................................................... 12 3.1.3 提取车间物料衡算 .......................................................................... 12 3.2 计算与设备选型 ..................................................................................... 13

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哈尔滨理工大学学士学位论文

3.2.1 预处理设备 ...................................................................................... 14 3.2.2 前处理车间技术要求 ...................................................................... 14 3.2.3 提取及浓缩设备 .............................................................................. 14 3.3 设备总表 ................................................................................................. 16 3.4 车间工艺平面布置说明 ......................................................................... 16 3.5 车间技术要求 ......................................................................................... 17 3.6 本章小节 ................................................................................................. 17 第4章 辅助设施设计 ...................................................................................... 19 4.1 辅助设施 ................................................................................................. 19 4.1.1 配电室 .............................................................................................. 19 4.1.2 通风 .................................................................................................. 19 4.1.3 洗手间、更衣间、消毒间和清洗间 .............................................. 19 4.1.4 满足土建要求 .................................................................................. 19 4.1.5 楼梯、安全门与人员通道 .............................................................. 19 4.1.6 采光 .................................................................................................. 19 4.1.7 办公区域 .......................................................................................... 20 4.2 环境保护与三废处理 ............................................................................. 20 4.2.1 废气 .................................................................................................. 20 4.2.2 废水 .................................................................................................. 20 4.2.3 废渣 .................................................................................................. 20 4.2.4 环境保护 .......................................................................................... 20 4.3 安全防护 ................................................................................................. 21 4.3.1 醇沉工段 .......................................................................................... 21 4.3.2 职业安全卫生 .................................................................................. 21 4.3.3 设备的安装 ...................................................................................... 21 4.3.4 安全操作 .......................................................................................... 21 4.4 其它 ......................................................................................................... 22 4.5 本章小节 ................................................................................................. 22 结论 .................................................................................................................... 23 致谢 .................................................................................................................... 24 参考文献 ............................................................................................................ 25 附录A ................................................................................................................ 26 附录B ................................................................................................................ 29

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