Correspondence Transfer for the Registration of Multimodal Images(11)

Gene expression data provide information on the location where certain genes are active; in order for this to be useful, such a location must be registered to an anatomical atlas. Because gene expression maps are considerably different from each other – t

Figure4.Somemorerepresentativeexampleswhereourcom-binedmodelyieldssubjectivelysuccessfulcorrespondenceofunilateralregions.Thetemplate(top-left),andtarget(top-right)aremappedoneontotheotherbyadeformation eld(bottom-left)thatyieldsthedeformedtemplate(bottomright).

4.1.Validationanddiscussion

AswehavediscussedinSect.2.1,nogroundtruthcanbeavailablefortheproblemweaddress.Thatis,unlesshigh-levelpriorknowledgeisbroughttobearthatouralgorithmdoesnotexploit.Ultimately,ouralgo-rithmwillhavetobecomplementedwithshapepriors,similarlytowhatdoneby[13].Fornow,however,welimitourselvestosubjectiveevaluationofourresultsbyexpertanatomists.Atthisstage,cross-validationandotherstatisticaltestscannotbeperformedbecause

there

Figure5.Exampleoflimitationsofourmodel.Fine-scalege-ometricfeatures(e.g.thesmallgaponthetoprightportionoftheatlas)arenotmappedcorrectlybecauseourmodelonlyuseslow-levelinformationandisnotcognizantofanatomicalstructureandconstraints.Itisclearthatpriorknowledgeofthegeometryoftheunderlyinganatomyhastobeenforcedtoachievethereliabilityandprecisionofhumanexperts.

isnosecondarytask(e.g.classi cation)forwhichwecouldhavegroundtruth.Itispossiblethatthesewillbecomeavailableinthefuture(e.g.post-mortemstud-iesofeachindividualsubject),butthatwouldnotbepractical.Ourhopeisthatourmodel,integratedwithsuitableshapepriors,canhelpsciencebyautomatingmulti-modalregistrationtasks.Ourexperimentsshowthatincludinganexplicitmodelofthecorrespondencehypothesisforbilateralversusunilateralregionsthereareimprovementsoverbothtraditionalintensity-basedregistration,aswellasovermutualinformation-basedapproaches.

Acknowledgements

ThisworkwassupportedbyAFOSRFA9550-06-1-0138.WethankGregorioGuidiandAndreaVedaldifortheircommentsandsuggestions,andErh-FangLeeandIvoDinovforprovidingdataandfeedback.

References

[1]M.A.Audette,F.P.Ferrie,andT.M.Peters.Anal-gorithmicoverviewofsurfaceregistrationtechniquesformedicalimaging.MedicalImageAnalysis,4:201–217,2000.3

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