布洛芬分散片的研制(4)

布洛芬分散片的研制

160.

2　黄胜炎.分散片进展[J.中国药学杂志,1992,27(4):226.3

遇水后能迅速膨胀、崩解,混悬液在一定时间内较稳

定,体外溶出度实验表明,分散片的溶出度远快于普通片。本处方完全采用国产辅料,来源易于保证;分散片的制备工艺简单,可采用普通片剂的生产设备生产,用适宜的辅料及制剂工艺制备分散片,可提高难溶性药物的生物利用度。

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[收稿日期:2001211227

Preparationofibuprofendispersibletablets

Abudukeyimi,Maierdan,HANHai-xia,etal

(DepartmentofPharmacy,FirstAffiliatedHospital,XinjiangMedicalUniversity,

Urumqi830054,China)

Abstract:Objective:Toselectoptimalcomposingoftheprescriptionofibuprofensoliddispersiontabletbyinvestigatingtheinfluenceofseveraldisintegrantstodisintegratetimelimited.Methods:UsingtheorthogonaldesignforselectingthebestamountsofCMS2Na,MCC,theappearanceoftablets,dissolutionrate,suspensibilityanddisintegrationtimewereasindex.Results:Thedissolutionofthattabletswasfast,couldbecompletelyformintosuspension,whichcouldscreenthroughthe710Λmmesh.Conclusion:ThequalityofibuprofendispersibletabletismostlyrelatedtotheamountsofCMS2Na,MCCandthebinderetc.eachindexofthattabletsconformstothedesign.Keywords:ibuprofen;dispersibletablets;orthogonaldesign(上接73页)

5　李春杰,刘德玺,买买提依明,等.骆驼蓬抗癌化学成分的分离

9　齐海,马特,王仁裕,等.骆驼蓬总生物碱治疗食管细胞淋癌

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国外医药植物药分10　王长虹,刘军,郑立明,等.不同产地骆驼蓬不同药用部位中

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生物碱的含量分析研究[J.

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中国药学杂志,2002,37(2):

乌鲁木齐:新

中国医科大学学报,1993,22(3):1822183.

8　胡海棠,潘启超.骆驼蓬总碱对鼠肝癌细胞周期学的影响[J.

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[收稿日期:2002203213

癌症,1993,12(6):4892491.

IdentificationofPeganumharmalaL.andPeganumnigellastrumBge.

usingHPLCandTLC

WANGChang-hong,LIUJun,LINYi-mei,etal

(DepartmentofPharmacy,SecondAffiliatedHospital,XinjiangMedicalUniversity,

Urumqi830028,China)

Abstract:Objective:ToestablishmethodtoidentifyPeganumharmalaL.andPeganumnigellastrumBge.Methods:BoththeHPLCandTLCwereemployedtoidentifyPeganumharmalaL.andPeganumnigellastrumBge.Results:TheresultsofHPLCandTLCshowedthattherewerealotofharmalineintherootofPeganumnigellastrumBge.buttherewasnoharmalineintherootofPeganumharmalaL.WhilethecontentofharminewashigherthanthatofharmalineinseedofPeganumharmalaL.,andthelevelofharmalinewashigherthanthatofharmineinseedofPeganumnigellastrumBge.Conclusions:TheHPLCandTLCcouldbeusedtoidentifyPeganumharmalaL.andPeganumnigellastrumBge.

Keywords:PeganumharmalaL.;PeganumnigellastrumBge.;harmaline;harmine;identification;HPLC;TLC

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