化药合成,抗肿瘤新药(13)

4.1.1

5.Methyl9-benzyl-b-carboline-3-carboxylate(5d).A mixture of5(2.26g,10mmol)and anhydrous DMF (60mL)was stirred at rt for10min,then60%NaH (0.6g,2mmol)and benzyl bromide(5mL,40mmol)were added and re?uxed ter the mixture was treated in a manner similar to that described for5a to a?ord white crystals5d(2.3g,73%),mp187–188°C(from petroleum

R.Cao et al./Bioorg.Med.Chem.12(2004)4613–46234619

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