化药合成,抗肿瘤新药(15)

3

):8.89(2H,m,H-4,H-1), 8.20–8.22(1H,d,J=7.5Hz,H-8),7.61–7.64(1H,m, H-5),7.41–7.42(1H,m,H-6),7.34–7.37(1H,m,H-7), 7.26–7.30(2H,m,Ar–H),7.19–7.22(1H,m,Ar–H), 7.13–7.15(2H,m,Ar–H), 4.52–4.57(2H,m, NC H2CH2CH2Ar), 4.41–4.44(2H,m,NCH2C H2-CH2Ar),2.70–2.73(2H,m,OC H2CH3),2.24–2.30(2H, m,NCH2CH2C H2Ar),1.49–1.52(3H,m,OCH2C H3). Anal.Calcd for C23H22N2O2:C,77.09;H, 6.15;N, 7.82.Found:C,76.88;H,6.38;N,7.75.

4.1.22.Butyl9-methyl-b-carboline-3-carboxylate(7a).A mixture of7(2.68g,10mmol)and anhydrous DMF (80mL)was stirred at rt for10min,then60%NaH (0.6g,15mmol)and iodomethane(2mL,30mmol)were added and stirred at rt ter the mixture was

4620R.Cao et al./Bioorg.Med.Chem.12(2004)4613–4623

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