Microarray analysis unmasked two siblings with pure hereditary spastic paraplegia shared a run of(2)

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Microarray analysis unmasked two siblings with pure hereditary spastic paraplegia shared a run of homozygosity region onchromosome 3q28–q29

352W.Yuetal./JournaloftheNeurologicalSciences359(2015)351–355

Fig.1.PedigreeoftheAR-HSPfamily.Thehaplotypesarecomposedof fteenmicrosatellitemarkersfromchromosome3q28–3q29.Longgreenbarsindicatethehomozygosityregionthatissharedbythetwopatients(betweenD3S1288toD3S3707).

7yearsago.Twoaffected(III-1andIII-2)andsixunaffectedmembers(II-2–4andII-6–8)wereexaminedbytwoexperiencedneurologists(Dr.Q-LSongandDr.JSu).Additionally,theaffectedindividualstooktheexaminationofmagneticresonanceimaging(MRI)andelectroen-cephalogram(EEG)analysis.

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