No apparent expression of MMP-9 was observed invehicle-treated rats, whereas administration of DESproduced diffuse expression of MMP-9. Co-adminis-tration of melatonin abolished MMP-9 expression inthe pituitary (Fig. 1). At week 16, expression of AQP-1 was increased in the endothelial cells of the pituitaryglands of rats receiving DES, which could not bealtered by melatonin administration (Fig. 1).
Effects of melatonin on VEGF, MMP-9,and AQP-1
In the vehicle-treated pituitary tissues, VEGF wasselectively expressed in pituitary cells surrounding
©Polish Histochemical et Cytochemical Society
Folia Histochem Cytobiol. 2010:48(2): 280(278-283) 10.2478/v10042-010-0023-1
Changes in ultrastructure
We previously reported in the DES-treated pituitary,electron microscopic investigation revealed well-developed rough endoplasmic reticulum (RER) andfaulty exocytosis in some cells, indicating the devel-
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